Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity
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چکیده
منابع مشابه
Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity
Corticotropin releasing factor (CRF) has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs). CRF has been associated with stress-induced drug reinforcement. Extensive literature has identified CRF to play an important role in the mol...
متن کاملCorticotropin releasing factor in neuroplasticity.
Stress is among the strongest signals promoting neuroplasticity: Stress signals, indicating real or perceived danger, lead to alterations of neuronal function and often structure, designed to adapt to the changed conditions and promote survival. Corticotropin releasing factor (CRF) is expressed and released in several types of neuronal populations that are involved in cognition, emotion and the...
متن کاملThe physiology of corticotropin-releasing factor (CRF).
Corticotropin-releasing factor (CRF) was characterized, purified and synthesized in 1981 by Vale. The composition of this 41 amino-acid peptide varies slightly from one species to another. Its principal origin is the paraventricular nucleus of the hypothalamus and, by the portal vessels, it reaches the adenohypophysis where it stimulates the corticotrophs. The effects of CRF have been analysed ...
متن کاملCorticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism.
S ensitization is a ubiquitous biological phenomenon that has a role in the neuroadaptation of many different functions, from learning and memory to stress responsivity. Historically, a specific form of sensitization termed psychomotor sensitization (mistermed in my view as ‘‘behavioral sensitization’’) is induced by repeated administration of drugs of abuse and has been linked to the neuroadap...
متن کاملCorticotropin-releasing factor (CRF) system localization in human fetal heart.
OBJECTIVE The corticotropin-releasing factor (CRF) family consists of the neuropeptides CRF, Ucn I, II and III and the binding sites CRFR1, CRFR2 and CRF-BP. It regulates stress response and the homeostasis of an organism. In this study, we examined the presence of the CRF system in the human hearts of normal and pathological fetuses. DESIGN Heart tissues from 40 archival human fetuses were d...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2012
ISSN: 1662-5099
DOI: 10.3389/fnmol.2012.00091